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DHEA Studies

Journal of Clinical Endocrinology & Metabolism, 2010

Low serum levels of DHEA(-S) predict death from all causes, CVD, and ischemic heart disease in older men.

Ohlsson C, Labrie F, Barrett-Connor E, Karlsson MK, et al. Low serum levels of dehydroepiandrosterone sulfate predict all-cause and cardiovascular mortality in elderly Swedish men. J Clin Endocrinol Metab. 2010 Sep; 95(9):4406-4414.

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Archives of Internal Medicine, 2007

Age-associated decline in anabolic hormone levels is a strong independent predictor of mortality in older men. Having multiple hormonal deficiencies rather than a deficiency in a single anabolic hormone is a robust biomarker of poor health status in older persons.

Maggio M, Lauretani F, Ceda GP, Bandinelli S, et al. Relationship between low levels of anabolic hormones and 6-year mortality in older men: the aging in the Chianti Area (InCHIANTI) study. Arch Intern Med. 2007 Nov;167(20):2249-2254.

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Critical Care Medicine, 2001

DHEA improves immune function and decreases mortality.

Oberbeck R, Dahlweid M, Koch R, van Griensven M, et al. Dehydroepiandrosterone decreases mortality rate and improves cellular immune function during polymicrobial sepsis. Critical Care Med. 2001 Feb;29(2):380-384.

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Journal of Clinical Endocrinology and Metabolism, 2008

Higher endogenous DHEAS levels are independently and favorably associated with executive function, concentration, and working memory.

Davis, SR, Shah, SM, et al. Dehydroepiandrosterone sulfate levels are associated with more favorable cognitive function in women. J Clin Endocrinol Metab. 2008 Mar; 93(3):801-808.

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Endokrynologia Polska, 2005

DHEA-S and testosterone deficiency were independently associated with higher insulin resistance and obesity.

Rabijewski M, Kozakowski J, Zgliczynski W. The relationship between testosterone and dehydroepiandrosterone sulfate concentrations, insulin resistance and visceral obesity in elderly men. Endokrynol Pol. 2005Nov-Dec; 56(6):897-903.

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Journal of the American Medical Association, 2004

DHEA replacement could play a role in prevention and treatment of the metabolic syndrome associated with abdominal obesity.

Villareal DT, Holloszy JO. Effect of DHEA on abdominal fat and insulin action in elderly women and men: A randomized controlled trial. JAMA. 2004;292(18):2243-2248.

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American Journal of Psychiatry, 1999

DHEA is beneficial in treatment of major depression in women.

Wolkowitz OM, Reus VI, Keebler A, Nelson N, Friedland M, et al. Double-blind treatment of major depression with dehydroepiandrosterone. Am J Psychiatry. 1999 Apr; 156(4):646-649.

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Journal of the American Geriatrics Society, 1999

Low DHEA levels are associated with depression and depressed mood.

Barrett-Connor E, von Muhlen D, Laughlin GA, Kripke A. Endogenous levels of dehydroepiandrosterone sulfate, but not other sex hormones, are associated with depressed mood in older women: the Rancho Bernardo Study. J Am Geriatr Soc. 1999 Jun;47(6):685-691.

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Gynecological Endocrinology, 2006

Long-term administration of DHEA to postmenopausal women modulated age-related changes in circulating androgens, progestins and adrenal function.

Genazzani, AR, Pluchino, N, Begliuomini, S, Stomati, M, Bernardi, F, Pieri, M, Casarosa, E, Palumbo, M, Genazzani, AD, Luisi, M. Long-term low-dose oral administration of dehydroepiandrosterone modulates adrenal response to adrenocorticotropic hormone in early and late postmenopausal women. Gynecol Endocrinol. 2006 Nov; 22(11): 627-635.

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Neuroendocrinology Letters, 2005

Chronic fatigue syndrome (CFS) is associated with lowered levels of DHEA and the latter may play a role in the pathophysiology of CFS.

Maes, M, Mihaylova, I, De Ruyter, M. Decreased dehydroepiandrosterone sulfate but normal insulin-like growth factor in chronic fatigue syndrome (CFS): relevance for the inflammatory response in CFS. Neuro Endocrinol Lett. 2005 Oct; 26(5):487-492.

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American Journal of Physiology, 2006

DHEA replacement has the beneficial effect of enhancing the increases in muscle mass and strength induced by heavy resistance exercise in elderly individuals.

Villareal, DT, Holloszy, JO. DHEA enhances effects of weight training on muscle mass and strength in elderly women and men. Am J Physiol Endocrinol Metab. 2006 Nov; 291(5): E1003-1008.

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Autoimmunity, 2005

Low dose DHEA treatment improves health-related quality of life with regard to mental well-being and sexuality.

Nordmark, G, Bengtsson, C, et al. Effects of dehydroepiandrosterone supplement on health-related quality of life in glucocorticoid treated female patients with systemic lupus erythematosus. Autoimmunity. 2005 Nov; 38(7):531-540.

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Psychopharmacology, 2006

Twenty-four healthy young men were given DHEA for seven days; DHEA administration improved memory and mood.

Alhaj, HA, Massey, AE, McAllister-Williams, RH. Effects of DHEA administration on episodic memory, cortisol and mood in healthy young men: a double-blind, placebo-controlled study. Psychopharmacology. 2006 Nov; 188(4):541-551.

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Endokrynologia Polska, 2005

Men between the ages of 41 to 60 were given DHEA for 40 days. Findings included a decrease in total cholesterol, insulin, glucose and fasting insulin resistance index (FIRI).

Rabjewski, M, Zgliczynski, W. Positive effects of DHEA therapy on insulin resistance and lipids in men with angiographically verified coronary heart disease–preliminary study. Endokrynol Pol. 2005; 56(6):904-910.

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American Journal of Epidemiology, 2001

Low DHEA and DHEAS levels are predictive of ischemic heart disease in men.

RFeldman, HA, et al. Low DHEA and ischemic heart disease in middle-aged men: prospective results from the Massachusetts Male Aging Study. Am J Epidemiol. 2001; 153:79-89.